CryoFlash is a benchtop instrument that melts and re-freezes a vitrified cryo‑EM sample in microseconds, in regions that you select. While the sample is liquid, proteins are made to perform their tasks. Re-freezing then traps their motions for standard cryo‑EM imaging.
CryoFlash uses precisely controlled laser pulses to melt and re-freeze regions that you select on a vitrified cryo‑EM sample. While the sample is liquid, a stimulus of your choice induces protein dynamics. When the laser stops, the sample re-freezes and the protein motion is trapped. Different regions can capture different time points on the same sample.
